SCHEMBL29648906

SCHEMBL29648906

O=C=Nc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP3A4 P08684 2/20 0.42
TRPA1 O75762 1/20 0.42
TSHR P16473 1/20 0.38
AR P10275 9/20 0.37
IDO1 P14902 2/20 0.36
SLC22A12 Q96S37 1/20 0.36
KIF11 P52732 1/20 0.34
HTR3E A5X5Y0 1/20 0.34
HTR3B O95264 1/20 0.34
HTR3A P46098 1/20 0.34
HTR3D Q70Z44 1/20 0.34
HTR3C Q8WXA8 1/20 0.34
MPL P40238 1/20 0.34
KMO O15229 1/20 0.34
PTPN7 P35236 1/20 0.33
DUSP3 P51452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL60206 1.00 MAPK1 (0.44) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL6895856 0.85 ALDH1A1 (0.43) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL4462791 0.85 KIF11 (0.45) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL30196175 0.85 KIF11 (0.45) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL1555041 0.85 MAPK1 (0.47) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL7177146 0.83 MAPK1 (0.46) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL30673506 0.81 P2RY6 (0.38) TDP1CYP3A4ARIDO1HTR3E
SCHEMBL3104369 0.81 CYP3A4 (0.50) MAPK1TDP1CYP3A4TRPA1TSHR
SCHEMBL1435515 0.81 P2RY6 (0.38) TDP1CYP3A4ARIDO1HTR3E
SCHEMBL28113838 0.81 TRPA1 (0.35) MAPK1TDP1CYP3A4TRPA1SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025128627-A1 FLUORINATED THERMOPLASTIC POLYURETHANE ABIOMED, INC. (US) 2025-06-19 WO claimed
CN-118016995-A Non-aqueous electrolyte containing aromatic isocyanate and lithium ion battery 诺莱特电池材料(苏州)有限公司 2024-05-10 CN claimed
WO-2025128627-A1 FLUORINATED THERMOPLASTIC POLYURETHANE ABIOMED, INC. (US) 2025-06-19 WO disclosed
US-20250188216-A1 FLUORINATED THERMOPLASTIC POLYURETHANE ABIOMED, INC. (US) 2025-06-12 US disclosed
CN-113262218-B Use of isothiocyanate compounds 无锡杰西医药股份有限公司 2024-06-18 CN disclosed
CN-118016995-A Non-aqueous electrolyte containing aromatic isocyanate and lithium ion battery 诺莱特电池材料(苏州)有限公司 2024-05-10 CN disclosed
CN-112020525-B Adducts of amine catalysts for preparing isocyanurate polymers 科思创知识产权两合公司 2023-05-16 CN disclosed
CN-115429785-A Composition for improving bioavailability and treatment effect of isothiocyanate compounds 无锡杰西医药股份有限公司 2022-12-06 CN disclosed
EP-3997149-A1 POLYMERIZABLE COMPOSITIONS FOR PREPARING POLYISOCYANURATE-BASED PLASTICS HAVING EXTENDED WORKLIFE Covestro Intellectual Property GmbH & Co. KG (DE) 2022-05-18 EP disclosed