SCHEMBL28113846

SCHEMBL28113846

O=C=Nc1c(Cl)cccc1C(F)(F)F.O=C=Nc1ccc(C(F)(F)F)cc1Cl.O=C=Nc1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 1/20 0.33
MAPT P10636 3/20 0.32
NPSR1 Q6W5P4 3/20 0.32
ALDH1A1 P00352 2/20 0.32
HTT P42858 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
MCL1 Q07820 2/20 0.32
MAPK1 P28482 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
DHFR P00374 1/20 0.32
POLQ O75417 1/20 0.32
LMNA P02545 1/20 0.32
HSP90AA1 P07900 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CRHR1 P34998 2/20 0.31
RORC P51449 1/20 0.31
RORB Q92753 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL162605 0.80 PDE2A (0.41) PDE2AMAPTALDH1A1MEN1KMT2A
SCHEMBL163538 0.80 GABRA1 (0.43) ALDH1A1SMN1; SMN2MEN1KMT2AMCL1
SCHEMBL29648890 0.80 PDE2A (0.41) PDE2AMAPTALDH1A1MEN1KMT2A
SCHEMBL27701883 0.70 TDP1 (0.36) ALDH1A1MAPK1TDP1
SCHEMBL11872782 0.70 TDP1 (0.38) PDE2AALDH1A1MAPK1TDP1
SCHEMBL11624082 0.70 CYP3A4 (0.40) MAPTNPSR1ALDH1A1HTTSMN1; SMN2
SCHEMBL8746808 0.70 TSHR (0.50) ALDH1A1MAPK1TDP1
SCHEMBL10905501 0.70 CES2 (0.46) PDE2AALDH1A1TDP1POLQ
SCHEMBL31135862 0.70 CES2 (0.46) PDE2AALDH1A1TDP1POLQ
SCHEMBL28211238 0.69 GABRA1 (0.45) ALDH1A1HTTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106232666-A Post-modification polycarbodiimide 巴斯夫欧洲公司 2016-12-14 CN disclosed