Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406805 | 0.80 | TRPV4 (0.37) | HPGDSMN1; SMN2KDM4EMAPK1TRPV4 | |
| SCHEMBL21886863 | 0.80 | PDE3A (0.44) | HPGDSMN1; SMN2PDE3AKDM4EMAPK1 | |
| SCHEMBL28048048 | 0.78 | KDM4E (0.43) | HPGDSMN1; SMN2PDE3AKDM4EMAPK1 | |
| SCHEMBL8519351 | 0.78 | SRC (0.39) | HPGDSMN1; SMN2KDM4EMAPK1TRPV4 | |
| SCHEMBL686987 | 0.76 | MRGPRX4 (0.51) | KDM4EL3MBTL1RAB9AALDH1A1GAA | |
| SCHEMBL9929711 | 0.76 | MEN1 (0.42) | HPGDSMN1; SMN2PDE3AKDM4EMAPK1 | |
| SCHEMBL8699691 | 0.69 | HSD11B1 (0.43) | KDM4EMAPK1LMNATSHRMAPT | |
| SCHEMBL23087507 | 0.69 | PDE3A (0.43) | HPGDSMN1; SMN2PDE3AKDM4ETRPV4 | |
| SCHEMBL435768 | 0.69 | TRPV4 (0.56) | TRPV4MAPTL3MBTL1RORCRAB9A | |
| SCHEMBL28922153 | 0.68 | KDM4E (0.34) | HPGDSMN1; SMN2PDE3AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986867-B | Heterocycle amine as PI3K inhibitor | 因塞特控股公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-109010343-A | The purposes of Pyrazolopyrimidine derivative treatment PI3K δ associated disease | 因赛特公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-104024253-B | Heterocyclic amines as PI3K inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-11-30 | — | — | CN | disclosed |