SCHEMBL28114488

SCHEMBL28114488

O=C1c2ccccc2-c2c(Br)ccc3cccc1c23

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 2/20 0.58
PABPC1 P11940 2/20 0.58
CYP3A4 P08684 1/20 0.58
CASP1 P29466 1/20 0.58
CASP7 P55210 1/20 0.58
ALDH1A1 P00352 4/20 0.55
CES1 P23141 3/20 0.55
CES2 O00748 2/20 0.55
BCHE P06276 2/20 0.55
MCL1 Q07820 1/20 0.55
CYP1B1 Q16678 1/20 0.51
MAOA P21397 2/20 0.47
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
MAPT P10636 4/20 0.47
MAPK1 P28482 3/20 0.47
POLB P06746 2/20 0.47
HTT P42858 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
PTPRC P08575 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30420926 0.87 ALDH1A1 (0.61) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL27833733 0.87 ALDH1A1 (0.61) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL2199764 0.85 ALDH1A1 (0.56) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL7746057 0.78 PABPC1 (0.91) DNMT1PABPC1CYP3A4CASP1CASP7
Anthraquinone SCHEMBL8859829 0.78 CYP3A4 (0.74) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL1235490 0.77 CYP3A4 (0.52) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL29679284 0.77 PTPRC (0.57) PABPC1CYP3A4ALDH1A1CES1CES2
SCHEMBL2079031 0.77 PTPRC (0.57) PABPC1CYP3A4ALDH1A1CES1CES2
Acenaphthoquinone SCHEMBL28105137 0.76 ALDH1A1 (0.94) DNMT1PABPC1CYP3A4CASP1CASP7
SCHEMBL4025023 0.75 DNMT1 (0.58) DNMT1PABPC1CYP3A4CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106147101-A A kind of cold resisting type waterproof material and preparation method thereof 张海棠 2016-11-23 CN disclosed