Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2301694 | 1.00 | TSHR (0.47) | TSHRTHRBALDH1A1CYP3A4TDP1 | |
| Acetic Acid SCHEMBL8775549 | 0.96 | TSHR (0.47) | TSHRTHRBALDH1A1CYP3A4TDP1 | |
| SCHEMBL28226548 | 0.96 | TSHR (0.50) | TSHRTHRBALDH1A1CYP3A4TDP1 | |
| SCHEMBL1057516 | 0.96 | TSHR (0.50) | TSHRTHRBALDH1A1CYP3A4TDP1 | |
| SCHEMBL4823985 | 0.96 | — | — | |
| SCHEMBL8921614 | 0.96 | — | — | |
| SCHEMBL22017 | 0.96 | — | — | |
| SCHEMBL6269152 | 0.96 | — | — | |
| Methacrylic Acid SCHEMBL655219 | 0.94 | TSHR (0.45) | TSHRTHRBALDH1A1CYP3A4TDP1 | |
| Methacrylic Acid SCHEMBL250051 | 0.94 | TSHR (0.45) | TSHRTHRBALDH1A1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106328871-A | Lithium ion secondary battery | 汽车能源供应公司 | 2017-01-11 | — | — | CN | disclosed |
| CN-106328996-A | Lithium ion secondary battery | 汽车能源供应公司 | 2017-01-11 | — | — | CN | disclosed |