Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17085839 | 0.97 | HIF1A (0.33) | HIF1AMAPTPDE4AKDRHTR3E | |
| SCHEMBL24380 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL28779669 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL7468053 | 0.94 | ALDH1A1 (0.32) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| SCHEMBL21936163 | 0.87 | — | — | |
| SCHEMBL239053 | 0.80 | — | — | |
| SCHEMBL29110713 | 0.79 | ADRB1 (0.33) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL4996657 | 0.78 | — | — | |
| Pyrimidine SCHEMBL29201194 | 0.78 | PLD1 (0.35) | HTR3EHTR3BADRB1HTR3AHTR3D | |
| Pyridine SCHEMBL28202857 | 0.78 | PLD1 (0.39) | HTR3EHTR3BADRB1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110093123-A | Bonding sheet and its manufacturing method and adhesiveness film | 日东电工株式会社 | 2019-08-06 | — | — | CN | disclosed |
| CN-110093110-A | Adhesive, curing adhesive composition, bonding sheet and its manufacturing method | 日东电工株式会社 | 2019-08-06 | — | — | CN | disclosed |
| CN-110072916-A | Sealing tape | 3M创新有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-104797363-B | Method for making silver nanostructures and copolymers useful in such method | 罗地亚经营管理公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-104136507-B | Protective film | 日东电工株式会社 | 2017-09-01 | — | — | CN | disclosed |
| CN-104105745-B | Polylactic acid film or thin slice and adhesive tape or piece | 日东电工株式会社 | 2017-08-25 | — | — | CN | disclosed |
| CN-106084598-A | One-piece type thin film, thin film, the manufacture method of semiconductor device and the manufacture method of protection chip | 日东电工株式会社 | 2016-11-09 | — | — | CN | disclosed |