Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.56 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28115351 | 0.79 | JAK2 (0.60) | JAK2JAK1TYK2JAK3HSD17B10 | |
| SCHEMBL27833940 | 0.73 | JAK2 (0.76) | JAK2JAK1TYK2JAK3HSD17B10 | |
| SCHEMBL140896 | 0.72 | JAK2 (1.00) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL3986640 | 0.67 | JAK2 (0.50) | JAK2JAK1TYK2JAK3PDE3B | |
| SCHEMBL28837064 | 0.67 | L3MBTL1 (0.51) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL28115356 | 0.67 | CNR2 (0.45) | HSD17B10LMNAMAPTHPGDNPC1 | |
| SCHEMBL13598015 | 0.67 | SERPINE1 (0.47) | JAK2JAK1TYK2JAK3PDE3B | |
| SCHEMBL3379271 | 0.66 | MAPK1 (0.65) | HSD17B10LMNAHPGDHTTRAB9A | |
| SCHEMBL27997819 | 0.65 | JAK2 (0.60) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL10272898 | 0.65 | RAB9A (0.65) | HSD17B10KDM4EHPGDNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106243012-A | New indole analog derivative and preparation method thereof | 北方民族大学 | 2016-12-21 | — | — | CN | disclosed |