Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 4/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | BHMT | Q93088 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28246455 | 0.84 | SLC1A2 (0.45) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| SCHEMBL28096521 | 0.84 | CHRM2 (0.32) | — | |
| Bromide SCHEMBL28084571 | 0.82 | CHRM2 (0.31) | — | |
| SCHEMBL28096063 | 0.81 | CA1 (0.31) | CA2 | |
| Aspartic Acid SCHEMBL28467895 | 0.80 | GRIK1 (0.44) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| SCHEMBL27747710 | 0.78 | — | — | |
| SCHEMBL27767825 | 0.74 | CA2 (0.38) | SLC1A2SLC1A1SLC1A3CA2MAPK1 | |
| Glutamic Acid SCHEMBL31454133 | 0.73 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Leucine SCHEMBL27822812 | 0.73 | SLC7A5 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| D-Glutamate SCHEMBL28179361 | 0.73 | SLC1A2 (0.49) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220566-A | Ionic liquid with amino acid and preparation method and application thereof | 辽宁大学 | 2016-12-14 | — | — | CN | disclosed |