SCHEMBL28115934

SCHEMBL28115934

COC(=O)C(F)(F)c1cnc(COC=O)cn1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28092254 0.80
SCHEMBL27991315 0.79 AGBL2 (0.36) CYP2C19
SCHEMBL16452386 0.73 MAPK1 (0.42) CYP2C19
SCHEMBL28951039 0.72 MAPK14 (0.30)
SCHEMBL16583134 0.71 MAPK1 (0.44) CYP2C19
SCHEMBL15360321 0.71 KDM4E (0.41) CYP2C19
SCHEMBL31292441 0.70 CYP2C19 (0.39) CYP2C19
SCHEMBL28092474 0.69
SCHEMBL27991313 0.69 CYP2C19 (0.35) CYP2C19
SCHEMBL28092253 0.68 SIRT6 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104245680-B Process for producing 5- (difluoromethyl) pyrazine-2-carboxylic acid and production intermediate thereof 卫材R&D管理有限公司 2016-11-23 CN disclosed