⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43356 | 0.77 | GPR35 (0.38) | — | |
| SCHEMBL9324324 | 0.74 | — | — | |
| SCHEMBL11561961 | 0.74 | — | — | |
| SCHEMBL319993 | 0.74 | — | — | |
| SCHEMBL18976164 | 0.74 | — | — | |
| SCHEMBL28186786 | 0.74 | TSHR (0.40) | — | |
| Hydrochloric Acid SCHEMBL29060489 | 0.72 | MAPT (0.33) | — | |
| SCHEMBL7760580 | 0.71 | — | — | |
| SCHEMBL11562409 | 0.71 | MAPT (0.37) | — | |
| SCHEMBL11487530 | 0.69 | DPP4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110386944-A | Di (hetero) aryl macrocycles for inhibiting protein kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2019-10-29 | — | — | CN | disclosed |
| CN-107987082-B | A kind of Preparation Method And Their Intermediate of Larotrectinib | 苏州东南药业股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-107987082-B | A kind of Preparation Method And Their Intermediate of Larotrectinib | 苏州东南药业股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-110156813-A | Heterocyclic compound as TRK inhibitor | 北京诺诚健华医药科技有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-109456331-A | Substituted pyrazolo [1,5-a ] pyrimidine compound, and pharmaceutical composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-109414442-A | (S) liquid preparation of-N- (5- ((R) -2- (2,5- difluorophenyl)-pyrrolidin-1-yl)-pyrazolo [1,5-A] pyrimidin-3-yl) -3- hydroxyl pyrrolidine -1- formamide | 洛克索肿瘤学股份有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109310694-A | METHODS OF TREATING PEDIATRIC CANCERS | 洛克索肿瘤学股份有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-107428760-A | Crystalline forms of (S) -N- (5- ((R) -2- (2, 5-difluorophenyl) -pyrrolidin-1-yl) -pyrazolo [1,5-a ] pyrimidin-3-yl) -3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate | 阵列生物制药公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106146400-A | Benzyl-1H-pyrazoles, benzyl-1H-azole derivatives and its production and use | 四川大学 | 2016-11-23 | — | — | CN | disclosed |