SCHEMBL28116479

SCHEMBL28116479

O=C(C1=CN=Cc2ccccc2S1)C1=CN=Cc2ccccc2S1

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.42
GPR84 Q9NQS5 2/20 0.33
BCHE P06276 2/20 0.32
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
KMT2A Q03164 1/20 0.30
ACHE P22303 1/20 0.30
NOX1 Q9Y5S8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27678770 0.72 TRPA1 (0.37) TRPA1BCHEMEN1LMNAKMT2A
SCHEMBL29116644 0.72 TRPA1 (0.46) TRPA1GPR84
SCHEMBL5637470 0.72 TRPA1 (0.46) TRPA1GPR84
SCHEMBL27460419 0.71 TRPA1 (0.42) TRPA1
SCHEMBL11569294 0.70 TRPA1 (0.44) TRPA1
SCHEMBL27621756 0.70 TRPA1 (0.44) TRPA1
SCHEMBL28619927 0.70 BCAT2 (0.42) TRPA1GPR84
SCHEMBL4912033 0.68 TRPA1 (0.33) TRPA1BCHE
SCHEMBL27432697 0.66 TRPA1 (0.37) TRPA1GPR84
SCHEMBL6655366 0.65 TRPA1 (0.39) TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116710425-A Pharmaceutical agents for the treatment of disorders involving lannodine receptors 阿姆果制药有限公司 2023-09-05 CN disclosed
CN-106243061-B A kind of synthesis technology of half quetiapine fumarate 广安凯特制药有限公司 2019-01-25 CN disclosed
CN-106243061-A A kind of synthesis technique of half quetiapine fumarate 广安凯特医药化工有限公司 2016-12-21 CN disclosed