SCHEMBL28119415

SCHEMBL28119415

O=C(O)c1ccc(C(F)(F)F)cc1F.[BiH3]

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.62
ALDH1A1 P00352 3/20 0.62
HPGD P15428 3/20 0.62
HSD17B10 Q99714 2/20 0.62
USP2 O75604 1/20 0.54
CYP2C19 P33261 1/20 0.54
GAA P10253 1/20 0.54
CES2 O00748 2/20 0.52
MRGPRX4 Q96LA9 1/20 0.48
SORT1 Q99523 2/20 0.48
PIM1 P11309 1/20 0.47
PIM2 Q9P1W9 1/20 0.47
HTT P42858 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
GRIK1 P39086 1/20 0.47
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
ALOX12 P18054 1/20 0.46
KMT2A Q03164 1/20 0.46
RXRA P19793 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL283914 0.98 KDM4E (0.65) KDM4EALDH1A1HPGDHSD17B10USP2
Hydrochloric Acid SCHEMBL6498102 0.96 KDM4E (0.62) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL27637456 0.87 CES2 (0.56) KDM4EALDH1A1HPGDHSD17B10USP2
Heptane SCHEMBL28836076 0.85 RARB (0.58) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL28188798 0.84 GAA (0.57) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL4464473 0.84 KIF11 (0.55) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL5356539 0.83 ALDH1A1 (0.47) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL15917732 0.83 KDM4E (0.47) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL10702656 0.82 GAA (0.55) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL29382489 0.82 ALDH1A1 (0.59) KDM4EALDH1A1HPGDHSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106459746-B Sequential functionalization of phosphorescent emitter layers 西门子公司 2019-08-02 CN claimed
CN-106459746-A Sequential functionalization of phosphorescent emitter layers 西门子公司 2017-02-22 CN disclosed