Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL1100290 | 0.94 | TSHR (0.63) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| Acrylic Acid SCHEMBL3027841 | 0.94 | TSHR (0.63) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| Acrylic Acid SCHEMBL2123019 | 0.94 | TSHR (0.63) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL673261 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL25281286 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL25228041 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL25275202 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL20503422 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL52064 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD | |
| SCHEMBL7111058 | 0.92 | TSHR (0.70) | TSHRALDH1A1CYP3A4HCAR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459664-A | Air-water barrier silicone coatings | CSL硅树脂公司 | 2017-02-22 | — | — | CN | claimed |
| CN-106459664-A | Air-water barrier silicone coatings | CSL硅树脂公司 | 2017-02-22 | — | — | CN | disclosed |