Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.50 |
| ▸ | KDM5C | P41229 | 4/20 | 0.48 |
| ▸ | KDM6B | O15054 | 3/20 | 0.48 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.48 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levulinic Acid SCHEMBL27872814 | 0.90 | LMNA (0.67) | EGLN1LMNATSHRALKBH5SUCNR1 | |
| Butyric Acid SCHEMBL10655751 | 0.87 | FFAR3 (0.65) | LMNATSHRPHF8KDM2AFFAR3 | |
| Mercaptopropionic Acid SCHEMBL28208849 | 0.85 | ACE (0.46) | EGLN1LMNATSHRALKBH5SUCNR1 | |
| Valeric Acid SCHEMBL27832145 | 0.83 | AKR1B1 (0.58) | LMNATSHROR51E2SLC22A6AKR1B1 | |
| Malonic Acid SCHEMBL27835596 | 0.82 | TSHR (0.53) | EGLN1LMNATSHRALKBH5SUCNR1 | |
| Propionic Acid SCHEMBL27702359 | 0.82 | FFAR3 (0.59) | EGLN1LMNATSHRPHF8KDM2A | |
| Dimethylformamide SCHEMBL27566666 | 0.82 | TSHR (0.53) | EGLN1LMNATSHRALKBH5SUCNR1 | |
| Hexanoate SCHEMBL5547721 | 0.81 | AKR1B1 (0.70) | LMNATSHROR51E2SLC22A6AKR1B1 | |
| Succinic Acid SCHEMBL5875148 | 0.81 | EGLN1 (0.69) | EGLN1LMNATSHRALKBH5SUCNR1 | |
| Dimethylformamide SCHEMBL9754300 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103951746-B | Preparation method of ergosterol artificial antigen | 上海烟草集团有限责任公司 | 2017-01-25 | — | — | CN | disclosed |