Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27869888 | 0.83 | PDK1 (0.53) | LMNAPDK1MAPTHCAR3TSHR | |
| SCHEMBL1263066 | 0.81 | LMNA (0.66) | LMNAPDK1CRHBPCRHR2MAPT | |
| SCHEMBL28443421 | 0.81 | LMNA (0.61) | LMNAPDK1CRHBPCRHR2MAPT | |
| SCHEMBL28126128 | 0.80 | LMNA (0.60) | LMNAPDK1CRHBPCRHR2MAPT | |
| SCHEMBL904579 | 0.79 | TDP1 (0.55) | CRHBPCRHR2MAPTTSHRMAPK1 | |
| SCHEMBL3440935 | 0.78 | LMNA (0.62) | LMNAPDK1CRHBPCRHR2MAPT | |
| SCHEMBL15088714 | 0.78 | LMNA (0.66) | LMNACRHBPCRHR2MAPTHCAR3 | |
| SCHEMBL441296 | 0.77 | LMNA (1.00) | LMNAMAPTHCAR3MEN1KMT2A | |
| SCHEMBL1162258 | 0.77 | LMNA (1.00) | LMNAMAPTHCAR3MEN1KMT2A | |
| SCHEMBL9188742 | 0.76 | TTR (0.51) | LMNAPDK1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106518850-B | A kind of chemical synthesis process of pimobendan | 青岛农业大学 | 2019-04-09 | — | — | CN | claimed |
| CN-106518850-A | Chemical synthesis method of Pimobendan | 青岛农业大学 | 2017-03-22 | — | — | CN | claimed |
| CN-106518850-B | A kind of chemical synthesis process of pimobendan | 青岛农业大学 | 2019-04-09 | — | — | CN | disclosed |
| CN-106518850-A | Chemical synthesis method of Pimobendan | 青岛农业大学 | 2017-03-22 | — | — | CN | disclosed |