Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781450 | 0.86 | LMNA (0.52) | LMNACRHBPCRHR2MAPTMEN1 | |
| SCHEMBL2002281 | 0.84 | VCAM1 (0.57) | LMNAMAPTMEN1KMT2APDK1 | |
| SCHEMBL7268272 | 0.84 | PDK1 (0.46) | LMNAMAPTPDK1TSHRALDH1A1 | |
| SCHEMBL1263066 | 0.83 | LMNA (0.66) | LMNACRHBPCRHR2MAPTMEN1 | |
| SCHEMBL11703265 | 0.82 | GPR35 (0.44) | LMNAPDK1TSHRALDH1A1ALOX15 | |
| SCHEMBL3440935 | 0.80 | LMNA (0.62) | LMNACRHBPCRHR2MAPTMEN1 | |
| SCHEMBL11631320 | 0.80 | TDP1 (0.53) | LMNAMAPTTSHRTDP1ALDH1A1 | |
| SCHEMBL28644813 | 0.80 | KMT2A (0.58) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL28443421 | 0.80 | LMNA (0.61) | LMNACRHBPCRHR2MAPTMEN1 | |
| SCHEMBL28126130 | 0.80 | LMNA (0.61) | LMNACRHBPCRHR2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111518081-A | Method for synthesizing pimobendan | 中国农业大学 | 2020-08-11 | — | — | CN | claimed |
| CN-106518850-B | A kind of chemical synthesis process of pimobendan | 青岛农业大学 | 2019-04-09 | — | — | CN | claimed |
| CN-107522663-A | The preparation method of UD-CG115BS.acardi key intermediate | 天津长芦华信化工股份有限公司 | 2017-12-29 | — | — | CN | claimed |
| CN-106518850-A | Chemical synthesis method of Pimobendan | 青岛农业大学 | 2017-03-22 | — | — | CN | claimed |
| CN-111518081-A | Method for synthesizing pimobendan | 中国农业大学 | 2020-08-11 | — | — | CN | disclosed |
| CN-106518850-B | A kind of chemical synthesis process of pimobendan | 青岛农业大学 | 2019-04-09 | — | — | CN | disclosed |
| CN-106518850-B | A kind of chemical synthesis process of pimobendan | 青岛农业大学 | 2019-04-09 | — | — | CN | disclosed |
| CN-107522663-A | The preparation method of UD-CG115BS.acardi key intermediate | 天津长芦华信化工股份有限公司 | 2017-12-29 | — | — | CN | disclosed |
| CN-106518850-A | Chemical synthesis method of Pimobendan | 青岛农业大学 | 2017-03-22 | — | — | CN | disclosed |
| CN-106518850-A | Chemical synthesis method of Pimobendan | 青岛农业大学 | 2017-03-22 | — | — | CN | disclosed |