Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14741986 | 0.98 | MAPT (0.48) | MAPTKMT2AHDAC6TSHRALDH1A1 | |
| SCHEMBL25002922 | 0.83 | KMT2A (0.56) | MAPTKMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL22027749 | 0.83 | KMT2A (0.42) | MAPTKMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL25002890 | 0.83 | MAP4K4 (0.51) | MAPTKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL13728355 | 0.82 | HDAC6 (0.50) | MAPTKMT2AHDAC6ALDH1A1HPGD | |
| SCHEMBL15349749 | 0.82 | ALDH1A1 (0.59) | MAPTKMT2ATSHRALDH1A1KDM4E | |
| SCHEMBL696116 | 0.80 | XDH (0.50) | MAPTKMT2AHDAC6TSHRALDH1A1 | |
| SCHEMBL25002930 | 0.80 | RAB9A (0.49) | MAPTKMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL29214336 | 0.80 | ALDH1A1 (0.56) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL20743540 | 0.79 | MAPK1 (0.44) | MAPTALDH1A1KDM4EMAPK1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106518845-A | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI基金会股份有限公司 | 2017-03-22 | — | — | CN | disclosed |