Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.54 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homophenylalanine SCHEMBL27675878 | 0.88 | GSR (0.65) | GSRCPB2GRIK1MMP2ALPI | |
| Homophenylalanine SCHEMBL14331297 | 0.88 | GSR (0.65) | GSRCPB2GRIK1MMP2ALPI | |
| Lysine SCHEMBL11276606 | 0.85 | THRB (0.58) | GSRCPB2MMP2PTGS1KMT2A | |
| SCHEMBL15929734 | 0.84 | MMP2 (0.57) | GSRCPB2GRIK1MMP2F2 | |
| Lysine SCHEMBL3907035 | 0.83 | GSR (0.67) | GSRCPB2GRIK1MMP2ALPI | |
| Lysine SCHEMBL28801083 | 0.83 | GSR (0.67) | GSRCPB2GRIK1MMP2ALPI | |
| D-Phenylalanine SCHEMBL8215749 | 0.82 | SLC7A5 (0.71) | GSRCPB2MMP2ALPIPKM | |
| Dl-Phenylalanine SCHEMBL20740843 | 0.82 | SLC7A5 (0.71) | GSRCPB2MMP2ALPIPKM | |
| Phenylalanine SCHEMBL21314200 | 0.82 | SLC7A5 (0.71) | GSRCPB2MMP2ALPIPKM | |
| Dl-Phenylalanine SCHEMBL20740839 | 0.82 | SLC7A5 (0.71) | GSRCPB2MMP2ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106466485-A | A kind of targeting ligand-drug coupling body with cell endocytic mediation function | 同宜医药开曼有限公司 | 2017-03-01 | — | — | CN | claimed |
| CN-106466484-A | A kind of many targeting ligand-drug coupling body with cell endocytic mediation function | 同宜医药开曼有限公司 | 2017-03-01 | — | — | CN | claimed |