Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL9346943 | 0.92 | THRB (0.60) | THRBGSRITGB3ITGA2BCPB2 | |
| Lysine SCHEMBL28133256 | 0.85 | GSR (0.57) | GSRCPB2MMP2PTGS1BLM | |
| Lysine SCHEMBL11276603 | 0.82 | THRB (0.71) | THRBGSRITGB3ITGA2BMMP2 | |
| (R)-Ibuprophen SCHEMBL8579043 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL8733957 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL44617 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL875767 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Ibuprofen SCHEMBL44616 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| (R)-Ibuprophen SCHEMBL29696062 | 0.82 | THRB (0.73) | THRBGSRITGB3ITGA2BMMP2 | |
| Dexibuprofen SCHEMBL379398 | 0.81 | THRB (0.72) | THRBGSRITGB3ITGA2BMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4341798-A | ANTIINFLAMMATORY AGENT | LABORATORI PROPHIN S.P.A. (IT) | 1982-07-27 | — | — | US | claimed |