Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090907 | 0.88 | HTR7 (0.46) | MAP4K4HTR7SRCGRIA1CACNG8 | |
| SCHEMBL2093499 | 0.84 | FFAR1 (0.36) | MAP4K4HTR7SRCALDH1A1GRIA1 | |
| SCHEMBL16429717 | 0.77 | RPS6KA3 (0.47) | ALDH1A1RPS6KA3CYP3A4MAOATSHR | |
| SCHEMBL8954027 | 0.74 | ALDH1A1 (0.48) | SRCALDH1A1GRIA1CACNG8RPS6KA3 | |
| SCHEMBL16431919 | 0.73 | MAP4K4 (0.56) | MAP4K4HTR7SRCALDH1A1GRIA1 | |
| SCHEMBL29557215 | 0.72 | MAP4K4 (0.51) | MAP4K4ALDH1A1CYP3A4MAOATSHR | |
| SCHEMBL21539290 | 0.72 | MAP4K4 (0.51) | MAP4K4ALDH1A1CYP3A4MAOATSHR | |
| SCHEMBL9848294 | 0.72 | RAB9A (0.44) | MAP4K4ALDH1A1 | |
| SCHEMBL12565770 | 0.71 | HTR7 (0.53) | MAP4K4HTR7SRCALDH1A1GRIA1 | |
| SCHEMBL28441441 | 0.70 | ALDH1A1 (0.50) | ALDH1A1CYP3A4TSHRPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104592211-B | Biphenyl compound and application thereof | 广东东阳光药业有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-104193731-B | A kind of urea substituted biphenyl class compound and combinations thereof and purposes | 广东东阳光药业有限公司 | 2017-03-15 | — | — | CN | disclosed |