Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 3/20 | 0.40 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537584 | 0.89 | ACHE (0.45) | MAPTKMT2AMEN1NPSR1ACP1 | |
| SCHEMBL2813939 | 0.88 | PRKAA2 (0.39) | MAPTKMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL2811978 | 0.87 | JAK2 (0.45) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL2813941 | 0.86 | ADORA3 (0.41) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2810273 | 0.86 | ADORA3 (0.41) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2812056 | 0.85 | CXCR3 (0.37) | MAPTKMT2AMEN1ALDH1A1KCNH3 | |
| SCHEMBL2812076 | 0.85 | ACHE (0.38) | KMT2AMEN1POLBSIGMAR1ACHE | |
| SCHEMBL2813810 | 0.84 | CXCR4 (0.45) | MAPTKMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL537754 | 0.84 | SMN1; SMN2 (0.40) | MAPTKMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL2812933 | 0.83 | CLK4 (0.41) | MAPTKMT2ALMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | MAPT 2947/4885KMT2A 2836/4885LMNA 2815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.