Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Chloroaniline SCHEMBL28135468 | 0.82 | ALDH1A1 (0.55) | NPC1RAB9AALOX12ALDH1A1L3MBTL1 | |
| SCHEMBL28841664 | 0.82 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL7683480 | 0.79 | ACHE (0.50) | NPC1RAB9AHPGDSMN1; SMN2ALDH1A1 | |
| Dimethylamine SCHEMBL8475782 | 0.78 | ACHE (0.60) | RAB9ARAPGEF4KDM4EALDH1A1ACHE | |
| SCHEMBL11789 | 0.75 | — | — | |
| SCHEMBL11735289 | 0.75 | ACHE (0.71) | NPC1RAB9AHPGDSMN1; SMN2RAPGEF4 | |
| SCHEMBL29350699 | 0.75 | — | — | |
| SCHEMBL27689143 | 0.74 | ALDH1A1 (0.55) | RAPGEF4KDM4EALDH1A1L3MBTL1LMNA | |
| Ammonia Solution, Strong SCHEMBL2551919 | 0.73 | — | — | |
| Methylamine SCHEMBL11826976 | 0.73 | ACHE (0.67) | NPC1RAB9AHPGDSMN1; SMN2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |