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Methylene Chloride

Methylene Chloride

SCHEMBL28135451

CC(=O)OC(=O)CC(F)(F)F.ClCCl

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL801 0.93 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10TDP1
Methylene Chloride SCHEMBL28135450 0.86 HTT (0.31) ALDH1A1
SCHEMBL28841925 0.80 ALDH1A1 (0.32) ALDH1A1TSHR
SCHEMBL800 0.78 ALDH1A1 (0.35) ALDH1A1
SCHEMBL7261664 0.76 HSD17B10 (0.44) ALDH1A1TSHRHSD17B10TDP1
SCHEMBL775457 0.75 ALDH1A1 (0.40) ALDH1A1TDP1
SCHEMBL1634881 0.75 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10TDP1
Methylene Chloride SCHEMBL28175675 0.73 ALDH1A1 (0.41) ALDH1A1TSHRHSD17B10TDP1
Methylene Chloride SCHEMBL3284833 0.72 ALDH1A1 (0.71) ALDH1A1TSHRHSD17B10TDP1
SCHEMBL2182293 0.72 ALDH1A1 (0.45) ALDH1A1TSHRHSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106928247-A Spiral shell oxindole compounds and its purposes as therapeutic agent 泽农医药公司 2017-07-07 — — CN disclosed
CN-103664973-B Spiro-oxindole compounds and their use as therapeutic agents 泽农医药公司 2017-04-19 — — CN disclosed