Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.43 |
| ▸ | NPY4R | P50391 | 1/20 | 0.43 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370778 | 0.89 | NOTUM (0.66) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL3649822 | 0.89 | NOTUM (0.66) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| Hydrochloric Acid SCHEMBL28144485 | 0.88 | NOTUM (0.63) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| Hydrochloric Acid SCHEMBL16237239 | 0.88 | NOTUM (0.63) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| Hydrochloric Acid SCHEMBL28843911 | 0.86 | NOTUM (0.61) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| Isopropyl Alcohol SCHEMBL11540475 | 0.81 | NOTUM (0.61) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL29195129 | 0.80 | NOTUM (0.59) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL931955 | 0.80 | TSHR (0.69) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL29453277 | 0.80 | TSHR (0.69) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| Butyramide SCHEMBL27710916 | 0.78 | LMNA (0.54) | TSHRRAB9AL3MBTL1NOTUMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106660997-B | Salts of monocyclic pyridine derivatives and crystals thereof | 卫材R&D管理有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-106660997-A | Salts of monocyclic pyridine derivatives and crystals thereof | 卫材R&D管理有限公司 | 2017-05-10 | — | — | CN | disclosed |