Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8440245 | 0.98 | MTNR1A (0.48) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| Formic Acid SCHEMBL28598514 | 0.94 | MTNR1A (0.45) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL28248972 | 0.89 | MTNR1A (0.41) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL28260890 | 0.87 | MTNR1A (0.40) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL9240061 | 0.86 | MTNR1A (0.51) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL5380872 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL30066901 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL27343077 | 0.83 | MTNR1A (0.48) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL28599443 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 | |
| SCHEMBL5370015 | 0.83 | MTNR1A (0.56) | MTNR1AMTNR1BOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | claimed |
| CN-108884106-A | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | 詹森药业有限公司 | 2018-11-23 | — | — | CN | claimed |
| CN-108794544-A | It is used to prepare the alpha-nickel diimine compound of asymmetry containing nitro, intermediate, the Preparation method and use of ultra-high molecular weight polyethylene | 中国科学院化学研究所 | 2018-11-13 | — | — | CN | claimed |
| CN-108794545-A | It is used to prepare the alpha-nickel diimine compound of asymmetry containing tertiary butyl, the Preparation method and use of ultra-high molecular weight polyethylene elastomer | 中国科学院化学研究所 | 2018-11-13 | — | — | CN | claimed |
| CN-106632506-A | 4,4'-difluorobenzhydryl containing asymmetric alpha-diimine nickel complex, and intermediate, preparation method and application thereof | 中国科学院化学研究所 | 2017-05-10 | — | — | CN | claimed |
| CN-113121562-B | Polycyclic compounds as inhibitors of bruton's tyrosine kinase | 詹森药业有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113121562-A | Polycyclic compounds as inhibitors of bruton's tyrosine kinase | 詹森药业有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-113105475-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108884106-A | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | 詹森药业有限公司 | 2018-11-23 | — | — | CN | disclosed |