Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 9/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 8/20 | 0.42 |
| ▸ | CFB | P00751 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28194957 | 1.00 | POLB (0.44) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL28241784 | 1.00 | POLB (0.44) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL28218557 | 0.94 | ALDH1A1 (0.42) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL28227215 | 0.94 | ALDH1A1 (0.42) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL28234120 | 0.87 | GBA1 (0.34) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL27842329 | 0.87 | GBA1 (0.34) | POLBL3MBTL1SPHK2SPHK1CFB | |
| SCHEMBL23107172 | 0.84 | POLB (0.41) | POLBL3MBTL1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL2185067 | 0.84 | L3MBTL1 (0.50) | POLBL3MBTL1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL2185063 | 0.84 | L3MBTL1 (0.50) | POLBL3MBTL1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL28230891 | 0.84 | S1PR1 (0.41) | POLBL3MBTL1ALDH1A1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108347943-A | HEPATITIS B CORE PROTEIN MODULATORS | 组装生物科学股份有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-106687446-A | 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible kinase inhibitors of T790M/WT-EGFR and uses thereof | 百济神州有限公司 | 2017-05-17 | — | — | CN | disclosed |