Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP6 | Q9GZR1 | 9/20 | 0.39 |
| ▸ | APAF1 | O14727 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 6/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476846 | 0.80 | CASP1 (0.50) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2785735 | 0.77 | KMT5A (0.51) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2773991 | 0.76 | CXCR4 (0.50) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL9215848 | 0.76 | HRH4 (0.56) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL3477403 | 0.74 | MAPT (0.48) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2787221 | 0.71 | KMT5A (0.54) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2773827 | 0.71 | HRH4 (0.43) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL3475816 | 0.70 | HRH4 (0.46) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2788861 | 0.70 | KMT5A (0.56) | SENP6APAF1MAPTSENP7GAA | |
| SCHEMBL2770739 | 0.69 | ALDH1A1 (0.53) | SENP6APAF1MAPTSENP7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152675-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008152223-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2008-12-18 | — | — | WO | disclosed |