SCHEMBL28140609

SCHEMBL28140609

CN(C(=O)Oc1cccnc1)C(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.49
CCNC P24863 1/20 0.46
CDK8 P49336 1/20 0.46
ALOX15 P16050 2/20 0.46
ALDH1A1 P00352 4/20 0.45
KDM4E B2RXH2 2/20 0.45
MEN1 O00255 2/20 0.45
GAA P10253 1/20 0.45
MAPK1 P28482 1/20 0.45
MAPT P10636 5/20 0.43
THRB P10828 1/20 0.43
USP2 O75604 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10635171 0.83 RAB9A (0.57) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL31524305 0.83 RAB9A (0.57) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL27389053 0.80 L3MBTL1 (0.53) KMT2AALDH1A1KDM4EMEN1MAPK1
SCHEMBL8128655 0.78 KMT2A (0.51) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL5648895 0.77 LIPE (0.56) KMT2AALDH1A1KDM4EMEN1NPSR1
SCHEMBL29473372 0.77 KMT2A (0.54) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL16005701 0.77 KMT2A (0.54) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL4670462 0.76 KMT2A (0.61) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL28245982 0.76 KMT2A (0.53) KMT2ACCNCCDK8ALOX15ALDH1A1
SCHEMBL16741071 0.75 CCNC (0.49) KMT2ACCNCCDK8ALOX15ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103497188-B The compound of regulation c fms and/or c kit activity and its application 普莱希科公司 2017-06-23 CN disclosed