Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353595 | 0.84 | KMT2A (0.48) | HPGDMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13102519 | 0.83 | HPGD (0.62) | HPGDMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL28141066 | 0.82 | ALDH1A1 (0.59) | HPGDMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18038102 | 0.81 | ALDH1A1 (0.56) | HPGDMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29575656 | 0.78 | HPGD (0.68) | HPGDMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL12327192 | 0.78 | HPGD (0.68) | HPGDMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL2014002 | 0.78 | MEN1 (0.72) | HPGDMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL14679392 | 0.78 | HDAC3 (0.64) | HPGDMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL28308952 | 0.77 | CYP3A4 (0.59) | HPGDMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL2502058 | 0.75 | RAB9A (0.69) | HPGDMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632092-B | A kind of 1,3- dimethyl -7- substituted quinazoline -2,4- cyclohexadione compounds and its synthetic method and application | 重庆智合生物医药有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-106632092-A | 1,3-dimethyl-7-substituted-quinazolinyl-2,4-diones, and synthesis method and application thereof | 重庆智合生物医药有限公司 | 2017-05-10 | — | — | CN | disclosed |