Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SOD3 | P08294 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL28865391 | 0.88 | MEN1 (0.39) | COMTOXTRAVPR1ARAB9AALDH1A1 | |
| SCHEMBL257689 | 0.86 | — | — | |
| Pyridine SCHEMBL28065595 | 0.74 | TSHR (0.39) | COMTOXTRAVPR1ARAB9AALDH1A1 | |
| SCHEMBL16687146 | 0.70 | — | — | |
| SCHEMBL16692488 | 0.70 | — | — | |
| SCHEMBL23505274 | 0.69 | PLD1 (0.46) | ALDH1A1ADRB1ADRB2NCF1PLD1 | |
| SCHEMBL27516034 | 0.69 | OXTR (0.45) | OXTRAVPR1AALDH1A1MEN1MAPT | |
| SCHEMBL2390106 | 0.69 | RAB9A (0.35) | COMTOXTRAVPR1ARAB9AALDH1A1 | |
| SCHEMBL15941963 | 0.68 | PLAT (0.49) | ALDH1A1MEN1MAPTPKMALOX15 | |
| SCHEMBL15950966 | 0.68 | MEN1 (0.64) | ALDH1A1MEN1MAPTPKMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105929082-B | A kind of method of Pyrazine and pyridine substance in separation determination saliva | 云南中烟工业有限责任公司 | 2018-08-21 | — | — | CN | claimed |
| CN-106715518-B | Conjugated polymer | 默克专利有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-109171004-A | A kind of compounding maple extract Maillard reaction fragrance, preparation method and the application in papermaking-method reconstituted tobaccos | 河南中烟工业有限责任公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-108593814-A | The quantitative detecting method of nitrogenous compound in a kind of white wine | 北京工商大学 | 2018-09-28 | — | — | CN | disclosed |
| CN-105330821-B | The copolymer of 2-glycidyl ether capped polysiloxane compound and non-aromatic polyamines | 罗门哈斯电子材料有限公司 | 2018-08-28 | — | — | CN | disclosed |
| CN-107460106-A | A kind of method of the content of alkyl pyrazine compound in raising vinegar | 福建农林大学 | 2017-12-12 | — | — | CN | disclosed |
| CN-105353045-B | The detection method of pyrazine compounds in a kind of Maotai-flavor liquor | 贵州省产品质量监督检验院 | 2017-09-22 | — | — | CN | disclosed |
| CN-106715518-A | Conjugated polymers | 默克专利有限公司 | 2017-05-24 | — | — | CN | disclosed |