Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435873 | 0.79 | ELANE (0.39) | BACE1MAPTSMN1; SMN2TP53TOP2A | |
| SCHEMBL31147003 | 0.79 | PSMB8 (0.35) | MAPTSMN1; SMN2TP53TOP2ARAB9A | |
| SCHEMBL5536407 | 0.79 | ELANE (0.44) | BACE1MAOBMAOAPIK3CDPIK3CB | |
| SCHEMBL20298203 | 0.79 | BACE1 (0.46) | BACE1MAOBMAOAPIK3CDPIK3CB | |
| SCHEMBL10012831 | 0.79 | BACE1 (0.37) | BACE1MAOBMAOAPIK3CDPIK3CB | |
| SCHEMBL23387540 | 0.77 | RAB9A (0.46) | MAOBMAPTSMN1; SMN2TP53RAB9A | |
| SCHEMBL22085386 | 0.75 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2TP53TOP2AL3MBTL1 | |
| SCHEMBL28353014 | 0.75 | — | — | |
| SCHEMBL5687096 | 0.75 | ELANE (0.43) | BACE1MAOBMAOAPIK3CDPIK3CB | |
| SCHEMBL28356888 | 0.75 | PIK3CD (0.35) | BACE1MAOBMAOAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236984-B2 | Compound and use thereof in the treatment of amyloidosis | PENTRAXIN THERAPEUTICS LTD. (GB) | 2012-08-07 | — | — | US | disclosed |
| US-20100249233-A1 | COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2010-09-30 | — | — | US | disclosed |
| EP-2203167-A1 | COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS | Pentraxin Therapeutics Limited (GB) | 2010-07-07 | — | — | EP | disclosed |
| US-7651746-B2 | Halogenated bisdiarylaminopolycyclic aromatic compounds and polymers thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-01-26 | — | — | US | disclosed |
| US-7531564-B2 | Substituted benzoxazoles as estrogenic agents | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| WO-2009040405-A1 | COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-04-02 | — | — | WO | disclosed |
| EP-1982713-A2 | Substituted benzoxazoles and analogues as estrogenic agents | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080255057-A1 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| US-20070167503-A1 | Substituted benzoxazoles as estrogenic agents | WYETH (US) | 2007-07-19 | — | — | US | disclosed |
| US-20070126345-A1 | Halogenated bisdiarylaminopolycylic aromatic compounds and polymers thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-06-07 | — | — | US | disclosed |
| US-7129258-B2 | Substituted benzoxazoles as estrogenic agents | WYETH (US) | 2006-10-31 | — | — | US | disclosed |
| WO-2006026316-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | WYETH (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20060046968-A1 | Prodrug substituted benzoxazoles as estrogenic agents | WYETH (US) | 2006-03-02 | — | — | US | disclosed |
| US-20050239851-A1 | Substituted benzoxazoles as estrogenic agents | WYETH (US) | 2005-10-27 | — | — | US | disclosed |
| WO-2005049546-A1 | HALOGENATED BISDIARYLAMINOPOLYCYLIC AROMATIC COMPOUNDS AND POLYMERS THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-06-02 | — | — | WO | disclosed |
| US-20050080117-A1 | Substituted benzoxazoles as estrogenic agents | WYETH (US) | 2005-04-14 | — | — | US | disclosed |
| US-6794403-B2 | FOR TREATING OR INHIBITING INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, ULCERATIVE PROCTITIS OR COLITIS PROSTATIC HYPERTROPHY, UTERINE LEIOMYOMAS, BREAST CANCER, ENDOMETRIAL CANCER, CARDIOVASCULAR DISEASE, ALZHEIMER'S DISEASE | WYETH | 2004-09-21 | — | — | US | disclosed |
| EP-1451165-A1 | SUBSTITUTED BENZOXAZOLES AND ANALOGUES AS ESTROGENIC AGENTS | Wyeth (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20030199562-A1 | Substituted benzoxazoles as estrogenic agents | WYETH | 2003-10-23 | — | — | US | disclosed |
| WO-2003050095-A1 | SUBSTITUTED BENZOXAZOLES AND ANALOGUES AS ESTROGENIC AGENTS | WYETH (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255057-A1 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | ESR1, CYP19A1, ESR2 | BACE1 2321/4885MAOB 2169/4885MAOA 1403/4885 |
| US-20050239851-A1 | Substituted benzoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | BACE1 3540/4885MAOB 2692/4885MAOA 1636/4885 |
| US-20050080117-A1 | Substituted benzoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | BACE1 3540/4885MAOB 2692/4885MAOA 1636/4885 |
| US-20030199562-A1 | Substituted benzoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | BACE1 3164/4885MAOB 3432/4885MAOA 3207/4885 |
| US-20100249233-A1 | COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS | TTR, APP, C1QBP | BACE1 60/4885MAOB 619/4885MAOA 876/4885 |
| US-20070167503-A1 | Substituted benzoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | BACE1 3540/4885MAOB 2692/4885MAOA 1636/4885 |
| US-20070126345-A1 | Halogenated bisdiarylaminopolycylic aromatic compounds and polymers thereof | AHR, AADAC, ARNT | BACE1 4256/4885MAOB 1014/4885MAOA 691/4885 |
| US-20060046968-A1 | Prodrug substituted benzoxazoles as estrogenic agents | ESR1, CYP19A1, ESR2 | BACE1 2321/4885MAOB 2169/4885MAOA 1403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.