Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.91 |
| ▸ | TSHR | P16473 | 1/20 | 0.91 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8735819 | 0.95 | ALDH1A1 (0.91) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL24056 | 0.95 | — | — | |
| SCHEMBL8518918 | 0.95 | ALDH1A1 (1.00) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL11421454 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| Ether SCHEMBL6548099 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL23495553 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL57013 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL2702056 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| Methyl Alcohol SCHEMBL3844218 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL273266 | 0.93 | ALDH1A1 (0.95) | ALDH1A1TSHRTHRBLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109929204-A | A kind of preparation of antistatic high impact-resistant acrylonitritrile-styrene resin resin | 深圳市鹏达兴泰新材料有限公司 | 2019-06-25 | — | — | CN | claimed |
| CN-106632465-A | Synthetic method for (2-ethylhexyl)(2,4,4'-trimehtyl amyl) phosphinic acid | 北京科技大学 | 2017-05-10 | — | — | CN | claimed |
| CN-109929204-A | A kind of preparation of antistatic high impact-resistant acrylonitritrile-styrene resin resin | 深圳市鹏达兴泰新材料有限公司 | 2019-06-25 | — | — | CN | disclosed |