Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13551948 | 0.80 | ENPP2 (0.46) | ENPP2PTGS2PTGS1SMN1; SMN2ELANE | |
| Boric Acid SCHEMBL28014845 | 0.80 | ALDH1A1 (0.47) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL9195881 | 0.76 | PTGS2 (0.41) | ENPP2PTGS2PTGS1SMN1; SMN2ELANE | |
| SCHEMBL7991386 | 0.76 | PPARA (0.61) | ENPP2PPARAALDH1A1LMNA | |
| Boric Acid SCHEMBL27989719 | 0.75 | ENPP2 (0.40) | ENPP2PTGS2PTGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL514383 | 0.75 | PTGS2 (0.65) | ENPP2PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL9036922 | 0.74 | PTGS2 (0.42) | ENPP2PTGS2PTGS1SMN1; SMN2ELANE | |
| SCHEMBL27920698 | 0.74 | CA1 (0.50) | ENPP2ELANEALDH1A1 | |
| SCHEMBL17501064 | 0.73 | ENPP2 (0.53) | ENPP2PTGS2SMN1; SMN2 | |
| SCHEMBL17312043 | 0.72 | CA1 (0.48) | ENPP2ELANEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110256427-A | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-110204544-A | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-106795156-B | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-106795156-A | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2017-05-31 | — | — | CN | disclosed |