Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28197945 | 0.85 | DAO (0.42) | DAOPDGFRBPDGFRAEGFRKDM4E | |
| SCHEMBL14012753 | 0.77 | HASPIN (0.37) | PDGFRBPDGFRAKDM4EMAP4K4MINK1 | |
| SCHEMBL14038256 | 0.77 | MAP4K4 (0.35) | PDGFRBPDGFRAKDM4EMAP4K4MINK1 | |
| SCHEMBL6004354 | 0.77 | HPGD (0.58) | DAOPDGFRBPDGFRAEGFRKDM4E | |
| SCHEMBL28378899 | 0.77 | ALDH1A1 (0.53) | PDGFRBPDGFRAKDM4EMAP4K4MINK1 | |
| SCHEMBL29663644 | 0.77 | ALDH1A1 (0.53) | PDGFRBPDGFRAKDM4EMAP4K4MINK1 | |
| SCHEMBL14012754 | 0.77 | MAP4K4 (0.33) | PDGFRBPDGFRAMAP4K4MINK1TNIK | |
| SCHEMBL27805672 | 0.75 | KEAP1 (0.46) | KDM4EKDM4AKDM4DKDM4CALDH1A1 | |
| SCHEMBL1067857 | 0.74 | KDM4E (0.59) | EGFRKDM4EALDH1A1GLAHTT | |
| SCHEMBL31544472 | 0.74 | KDM4E (0.59) | EGFRKDM4EALDH1A1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795147-A | Cyclopropyl fused thiazine-2-amine compounds as beta-secretase inhibitors and methods of use | 美国安进公司 | 2017-05-31 | — | — | CN | disclosed |