Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28149552 | 0.85 | DAO (0.42) | DAOKDM4EMAPKAPK2EGFRPDGFRB | |
| SCHEMBL5598552 | 0.80 | GAA (0.39) | KDM4EPDGFRBPDGFRACSNK1DCSNK1E | |
| SCHEMBL3892453 | 0.77 | KDM4E (0.58) | DAOKDM4EMAPKAPK2EGFRPDGFRB | |
| SCHEMBL27784056 | 0.75 | KEAP1 (0.46) | KDM4EALDH1A1HPGDMAPTKDM4A | |
| SCHEMBL255425 | 0.74 | CLK1 (0.48) | DAOKDM4EMAPKAPK2EGFRCSNK1D | |
| SCHEMBL1067857 | 0.74 | KDM4E (0.59) | KDM4EEGFRALDH1A1GLAHPGD | |
| SCHEMBL31544472 | 0.74 | KDM4E (0.59) | KDM4EEGFRALDH1A1GLAHPGD | |
| SCHEMBL24868087 | 0.73 | DAO (0.39) | DAOKDM4EMAPKAPK2EGFRPDGFRB | |
| SCHEMBL3894130 | 0.73 | DAO (0.39) | DAOKDM4EMAPKAPK2EGFRPDGFRB | |
| SCHEMBL5262554 | 0.73 | NCOA3 (0.45) | KDM4ECLK1DYRK1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107667108-A | NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS | 施万生物制药研发IP有限责任公司 | 2018-02-06 | — | — | CN | disclosed |