SCHEMBL2814975

SCHEMBL2814975

COc1ccc(C(=O)Nc2ccc(C3(CNC(=O)C(C)(C)C)CCCC3)cc2)cc1OC

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.59
MEN1 O00255 5/20 0.59
NPC1 O15118 2/20 0.59
RAB9A P51151 2/20 0.59
KDM4E B2RXH2 1/20 0.57
TSHR P16473 1/20 0.55
CASP1 P29466 1/20 0.55
LMNA P02545 2/20 0.54
G6PD P11413 1/20 0.54
USP2 O75604 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
HTT P42858 1/20 0.51
TDP1 Q9NUW8 1/20 0.50
MAPT P10636 1/20 0.49
ALDH1A1 P00352 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2814801 0.89 KMT2A (0.62) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL2817053 0.89 TSHR (0.71) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL4436370 0.84 KMT2A (0.51) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL2817622 0.84 TSHR (0.64) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL2815498 0.84 KMT2A (0.67) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL2814692 0.83 KMT2A (0.66) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL10073048 0.81 LMNA (0.77) KMT2AMEN1TSHRCASP1LMNA
SCHEMBL10073037 0.79 MEN1 (0.84) KMT2AMEN1TSHRCASP1LMNA
SCHEMBL2817570 0.76 KMT2A (0.76) KMT2AMEN1NPC1RAB9AKDM4E
SCHEMBL2814616 0.76 KMT2A (0.76) KMT2AMEN1NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2010-09-30 US disclosed
CN-101679215-A New benzamide derivatives as the follicle stimulating hormone conditioning agent ADDEX PHARMA SA 2010-03-24 CN disclosed
EP-2134676-A2 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE Addex Pharma SA (CH) 2009-12-23 EP disclosed
WO-2008117175-A2 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2008-10-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE FSHR, GNRHR, SHBG KMT2A 1767/4885MEN1 150/4885NPC1 3400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.