Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27701156 | 0.77 | MAPT (0.31) | GAAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17315362 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27721875 | 0.71 | MAPT (0.37) | GAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27659878 | 0.70 | PARP1 (0.37) | MAPT | |
| SCHEMBL27721773 | 0.69 | RET (0.31) | GAAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28151098 | 0.68 | GLA (0.33) | ALKGLAGAAMAPT | |
| SCHEMBL27774969 | 0.66 | CNR2 (0.31) | — | |
| SCHEMBL17315432 | 0.64 | PARP1 (0.54) | GAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27735476 | 0.63 | ALDH1A1 (0.39) | GAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL25691830 | 0.63 | MCHR1 (0.47) | MAPTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106794181-A | MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions | 托马斯·黑勒戴药物研究基金会 | 2017-05-31 | — | — | CN | disclosed |