Leucine

Leucine

SCHEMBL28154235

CC(C)CC(N)C(=O)O.c1c[nH]cn1

nearest known ligand 0.58

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.58
SLC1A3 P43003 6/20 0.47
SLC1A2 P43004 6/20 0.47
ALDH1A1 P00352 1/20 0.42
FKBP5 Q13451 1/20 0.42
SLC1A1 P43005 6/20 0.41
AAK1 Q2M2I8 1/20 0.38
CYP3A4 P08684 1/20 0.37
GRIK1 P39086 5/20 0.37
GRIA2 P42262 2/20 0.37
GRIA4 P48058 2/20 0.37
GRIK3 Q13003 2/20 0.37
GRIK5 Q16478 2/20 0.37
GRIK2 Q13002 2/20 0.37
GRIA1 P42261 1/20 0.37
ANPEP P15144 1/20 0.35
RNPEP Q9H4A4 1/20 0.35
DNPEP Q9ULA0 1/20 0.35
LARS1 Q9P2J5 1/20 0.33
CIT O14578 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aspartic Acid SCHEMBL28155193 0.83 ALDH1A1 (0.45) SLC7A5SLC1A3SLC1A2ALDH1A1FKBP5
Imidazole SCHEMBL28128892 0.83 ALDH1A1 (0.45) SLC7A5SLC1A3SLC1A2ALDH1A1FKBP5
Alanine SCHEMBL8532370 0.83 ALDH1A1 (0.52) SLC7A5ALDH1A1FKBP5CYP3A4
Alanine SCHEMBL8532378 0.83 ALDH1A1 (0.52) SLC7A5ALDH1A1FKBP5CYP3A4
Serine SCHEMBL424445 0.81 ALDH1A1 (0.46) SLC7A5SLC1A3SLC1A2ALDH1A1FKBP5
Serine SCHEMBL424443 0.81 ALDH1A1 (0.46) SLC7A5SLC1A3SLC1A2ALDH1A1FKBP5
Norvaline SCHEMBL29109613 0.81 SLC1A2 (0.42) SLC7A5SLC1A3SLC1A2ALDH1A1FKBP5
Cysteine SCHEMBL28497338 0.80 PTGS1 (0.55) SLC7A5ALDH1A1FKBP5CYP3A4GRIK1
Leucine SCHEMBL28356659 0.79 SLC7A5 (0.72) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1
Leucine SCHEMBL5874172 0.79 SLC7A5 (0.72) SLC7A5SLC1A3SLC1A2SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106966988-A A kind of method of use microwave radiation synthesizing amino acid imidazole salts in aqueous 上海应用技术大学 2017-07-21 CN disclosed