Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL424443 | 1.00 | ALDH1A1 (0.46) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Serine SCHEMBL7585491 | 0.95 | ALDH1A1 (0.42) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Serine SCHEMBL29269863 | 0.94 | ALDH1A1 (0.41) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Cysteine SCHEMBL28497338 | 0.84 | PTGS1 (0.55) | ALDH1A1FKBP5SLC7A5CYP3A4PTGS1 | |
| Aspartic Acid SCHEMBL28155193 | 0.84 | ALDH1A1 (0.45) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Imidazole SCHEMBL28128892 | 0.84 | ALDH1A1 (0.45) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| D-Glutamate SCHEMBL28561964 | 0.81 | GRM8 (0.58) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Norvaline SCHEMBL29109613 | 0.81 | SLC1A2 (0.42) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Glutamic Acid SCHEMBL28561963 | 0.81 | GRM8 (0.58) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 | |
| Leucine SCHEMBL28154235 | 0.81 | SLC7A5 (0.58) | ALDH1A1FKBP5SLC7A5CYP3A4SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114014-A1 | B-LACTAM COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-27 | — | — | US | disclosed |
| US-9469610-B2 | β-lactam compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-18 | — | — | US | disclosed |
| US-8946408-B2 | Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-02-03 | — | — | US | disclosed |
| US-20120184731-A1 | Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2012-07-19 | — | — | US | disclosed |
| US-20120022248-A1 | B-LACTAM COMPOUNDS | The Regents of the University of Technology Office of Technology Transfer (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2011115613-A1 | A METHOD FOR SYNTHESIZING BETA-LACTAM COMPOUNDS BY DECOMPOSITION OF AN ALPHA-DIAZO-BETA-KETOAMIDE USING A FLUORESCENT LIGHT SOURCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010105267-A2 | β-LACTAM COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022248-A1 | B-LACTAM COMPOUNDS | COASY, BBOX1, GNE | ALDH1A1 2472/4885FKBP5 1240/4885SLC7A5 1860/4885 |
| US-20120184731-A1 | Method for synthesizing beta lactam compounds by decomposition of an alpha-diazo-beta-ketoamide using a fluorescent light source | PTMA, GLA, GLB1 | ALDH1A1 937/4885FKBP5 846/4885SLC7A5 3227/4885 |
| US-20170114014-A1 | B-LACTAM COMPOUNDS | COASY, BBOX1, GNE | ALDH1A1 2472/4885FKBP5 1240/4885SLC7A5 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.