Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL4970585 | 0.84 | TSHR (0.46) | ALDH1A1TSHRFGFR4DNM1BBOX1 | |
| Acrylamide SCHEMBL134959 | 0.82 | TSHR (0.48) | ALDH1A1TSHRFGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL28603972 | 0.82 | TSHR (0.48) | ALDH1A1TSHRFGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL15284746 | 0.80 | DNM1 (0.59) | DNM1 | |
| Acrylamide SCHEMBL28584493 | 0.80 | DNM1 (0.59) | DNM1 | |
| Acrylamide SCHEMBL15283952 | 0.80 | DNM1 (0.59) | DNM1 | |
| Acrylamide SCHEMBL3636541 | 0.79 | TSHR (0.50) | ALDH1A1TSHRFGFR4CHRM2CHRM4 | |
| Acrylamide SCHEMBL3892742 | 0.79 | TSHR (0.41) | ALDH1A1TSHRFGFR4 | |
| Acrylamide SCHEMBL28232213 | 0.78 | TSHR (0.44) | ALDH1A1TSHRFGFR4CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9165278 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104841482-B | A kind of polymer-modified nano-noble metal catalyst and preparation method thereof | 沈阳理工大学 | 2017-06-30 | — | — | CN | disclosed |