Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28157321 | 0.84 | TP53 (0.44) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL28156782 | 0.83 | LMNA (0.42) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL28156802 | 0.83 | HDAC4 (0.54) | MAPTLMNAPOLBRAB9ATP53 | |
| SCHEMBL28156810 | 0.82 | MAPT (0.42) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL16246499 | 0.81 | CFTR (0.50) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL28157313 | 0.80 | RXFP1 (0.46) | MAPTLMNAPOLBTP53MEN1 | |
| SCHEMBL28846370 | 0.80 | GSTO1 (0.42) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL28157364 | 0.80 | LMNA (0.45) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL28156807 | 0.79 | MEN1 (0.53) | MAPTPOLBRAB9ANPC1TP53 | |
| SCHEMBL28157305 | 0.77 | MEN1 (0.48) | MAPTLMNAPOLBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |