Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156802 | 0.91 | HDAC4 (0.54) | MEN1KMT2APOLBMAPTTNF | |
| SCHEMBL28157313 | 0.90 | RXFP1 (0.46) | MEN1KMT2APOLBMAPTTNF | |
| SCHEMBL28157283 | 0.85 | KDM4E (0.53) | MEN1KMT2APOLBKDM4ENPSR1 | |
| SCHEMBL16263745 | 0.82 | CFTR (0.59) | MEN1KMT2APOLBKDM4ENPSR1 | |
| SCHEMBL28846370 | 0.82 | GSTO1 (0.42) | MEN1KMT2APOLBKDM4ETDP1 | |
| SCHEMBL28156782 | 0.81 | LMNA (0.42) | MEN1KMT2APOLBKDM4ETDP1 | |
| SCHEMBL28156810 | 0.80 | MAPT (0.42) | MEN1KMT2APOLBTDP1MAPT | |
| SCHEMBL28157366 | 0.79 | MAPT (0.41) | MEN1KMT2APOLBKDM4ETDP1 | |
| SCHEMBL28157364 | 0.78 | LMNA (0.45) | MEN1KMT2APOLBKDM4ETDP1 | |
| SCHEMBL28846481 | 0.78 | MEN1 (0.47) | MEN1KMT2APOLBMAPTTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |