SCHEMBL28164104

SCHEMBL28164104

NS(=O)(=O)c1ccc(CC2CCC(c3ccccc3)CC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 12/20 0.54
CA2 P00918 12/20 0.54
CA9 Q16790 10/20 0.54
CA12 O43570 6/20 0.54
CA7 P43166 6/20 0.54
CA14 Q9ULX7 4/20 0.54
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
DUSP3 P51452 1/20 0.53
PTPN5 P54829 1/20 0.53
PTPN11 Q06124 1/20 0.53
HTT P42858 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
KDM1A O60341 1/20 0.49
MAOA P21397 1/20 0.49
ALDH1A1 P00352 1/20 0.47
CA4 P22748 3/20 0.44
CA5A P35218 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30269786 0.86 CA2 (0.56) CA1CA2CA9CA12CA7
SCHEMBL27533679 0.81 GBA1 (0.57) ALDH1A1
SCHEMBL5160716 0.78 CA2 (0.54) CA1CA2CA9CA12CA7
SCHEMBL8323422 0.77 CA2 (0.52) CA1CA2CA9CA12CA7
SCHEMBL28164115 0.77 GAA (0.61) CA1CA2CA9CA12CA7
SCHEMBL27917814 0.75 GBA1 (0.56) CA1CA2CA9CA12CA7
Hydrochloric Acid SCHEMBL4777109 0.74 GBA1 (0.54) CA1CA2CA9CA12CA7
SCHEMBL7752564 0.73 MEN1 (0.52) MEN1KMT2AMAOA
SCHEMBL27200509 0.72 CA2 (0.70) CA1CA2CA9CA12CA7
Hydrochloric Acid SCHEMBL8890221 0.72 CYP19A1 (0.53) KDM1AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106999450-A immunomodulator 弗莱塞斯生物科学公司 2017-08-01 CN disclosed