Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL60768 | 0.85 | FFAR3 (0.44) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Bicarbonate SCHEMBL378701 | 0.85 | FFAR3 (0.44) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Propene SCHEMBL28217121 | 0.85 | MEN1 (0.40) | ALDH1A1TSHRMEN1POLBKMT2A | |
| Acrylic Acid SCHEMBL2413568 | 0.83 | LMNA (0.56) | ALDH1A1TSHRMEN1POLBKMT2A | |
| Bicarbonate SCHEMBL4800891 | 0.82 | FFAR3 (0.41) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Bicarbonate SCHEMBL7091018 | 0.82 | ALDH1A1 (0.45) | ALDH1A1TSHRFFAR3LMNAMAPT | |
| Bicarbonate SCHEMBL4800886 | 0.82 | FFAR3 (0.41) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Bicarbonate SCHEMBL28088226 | 0.82 | FFAR3 (0.41) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Bicarbonate SCHEMBL4312446 | 0.82 | FFAR3 (0.41) | ALDH1A1TSHRFFAR3CHRM2CHRM4 | |
| Bicarbonate SCHEMBL28065786 | 0.82 | FFAR3 (0.41) | ALDH1A1TSHRFFAR3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105940460-B | Reactive resin compositions, circuit pattern and circuit substrate | 株式会社大阪曹达 | 2017-10-31 | — | — | CN | disclosed |