Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289887 | 0.78 | GAA (0.68) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27865770 | 0.78 | ALDH1A1 (0.55) | GAANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL3192014 | 0.78 | LMNA (0.77) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8215174 | 0.78 | GAA (1.00) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL28194390 | 0.77 | HDAC3 (0.59) | HDAC1HDAC6HDAC3PRSS1CA12 | |
| SCHEMBL27938991 | 0.77 | NPC1 (0.62) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL29114683 | 0.76 | HDAC1 (0.63) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL619878 | 0.76 | GAA (0.71) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5858228 | 0.76 | GAA (0.71) | GAANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1628440 | 0.75 | GAA (0.63) | GAANPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109574927-A | N- (substituted sulphonyl) benzamide derivatives and preparation method thereof and medical usage | 浙江海正药业股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-104718188-B | The benzamides of N- substitutions and its purposes in treating pain | 基因泰克公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-107835805-A | Substituted benzamides and methods of use thereof | 基因泰克公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107428683-A | N sulphonyl yl-benzamide derivatives, its preparation method and the purposes pharmaceutically of heterocyclic substituted | 上海海雁医药科技有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107406380-A | N sulphonyl yl-benzamide derivatives, its preparation method and the purposes pharmaceutically of heterocyclic substituted | 上海海雁医药科技有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107207430-A | Heterocyclic substituted N-sulfonyl benzamide derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2017-09-26 | — | — | CN | disclosed |