Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817328 | 1.00 | MCHR1 (0.64) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL418820 | 0.94 | MCHR1 (0.71) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL418821 | 0.94 | MCHR1 (0.71) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL2813040 | 0.89 | RAB9A (0.62) | MCHR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2813037 | 0.89 | RAB9A (0.62) | MCHR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2813850 | 0.89 | RAB9A (0.62) | MCHR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL416788 | 0.87 | MCHR1 (0.69) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL416789 | 0.87 | MCHR1 (0.69) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL13129522 | 0.86 | MCHR1 (0.66) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL13129515 | 0.86 | MCHR1 (0.65) | MCHR1NPC1RAB9ASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609731-B2 | Substituted tetrahydronaphthalenes, process for the preparation thereof and the use thereof as medicaments | SANOFI (FR) | 2013-12-17 | — | — | US | disclosed |
| US-20100249097-A1 | NOVEL SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249097-A1 | NOVEL SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS | DHPS, CYP11B2, CYP11B1 | MCHR1 2699/4885NPC1 403/4885RAB9A 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.