SCHEMBL28175199

SCHEMBL28175199

CC(=O)c1[c]c(C(C)=O)c2ccccc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.46
HPGD P15428 5/20 0.46
MAPT P10636 3/20 0.46
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
KDM4E B2RXH2 5/20 0.40
CYP1A2 P05177 2/20 0.40
HSD17B10 Q99714 2/20 0.40
GLA P06280 1/20 0.40
CYP2C19 P33261 1/20 0.40
NSD2 O96028 1/20 0.36
POLB P06746 1/20 0.36
MCL1 Q07820 1/20 0.36
MAOB P27338 2/20 0.36
TRPM4 Q8TD43 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
CA12 O43570 1/20 0.33
NT5E P21589 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5401761 0.71 ALDH1A1 (0.37) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL7308954 0.70 ALDH1A1 (0.44) ALDH1A1HPGDMAPTKMT2AKDM4E
SCHEMBL2995194 0.70 KLK7 (0.47) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL67303 0.69 ALDH1A1 (0.65) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL29491183 0.69 ALDH1A1 (0.65) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL293511 0.68 ALDH1A1 (0.38) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL7308184 0.67 ALDH1A1 (0.62) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL50624 0.66 ALDH1A1 (0.56) ALDH1A1HPGDMAPTMEN1KMT2A
SCHEMBL11645110 0.66 ALDH1A1 (0.51) ALDH1A1HPGDMAPTKDM4EHSD17B10
SCHEMBL692620 0.66 MEN1 (0.50) ALDH1A1HPGDMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107177038-A The compounds of class MOF 5, the preparation method and application of moisture resistant 辽宁师范大学 2017-09-19 CN claimed
CN-107177038-A The compounds of class MOF 5, the preparation method and application of moisture resistant 辽宁师范大学 2017-09-19 CN disclosed