Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17390834 | 0.79 | GLS (0.48) | L3MBTL1TDP1SMN1; SMN2GLSGAA | |
| SCHEMBL2640223 | 0.74 | TSHR (0.70) | L3MBTL1TDP1HRH4HRH3TSHR | |
| SCHEMBL15480812 | 0.74 | ALDH1A1 (0.52) | GLSHPGDHSD17B10TSHR | |
| SCHEMBL11925834 | 0.73 | TSHR (0.44) | L3MBTL1TDP1GLSHRH4HRH3 | |
| SCHEMBL3446778 | 0.72 | TDP1 (0.75) | L3MBTL1TDP1HRH4HRH3TSHR | |
| SCHEMBL20534698 | 0.72 | TDP1 (0.75) | L3MBTL1TDP1HRH4HRH3TSHR | |
| SCHEMBL941253 | 0.72 | TSHR (0.56) | L3MBTL1TDP1HRH4HRH3HPGD | |
| SCHEMBL9011734 | 0.72 | TSHR (0.67) | L3MBTL1TDP1SMN1; SMN2HRH4HRH3 | |
| SCHEMBL9011595 | 0.72 | TSHR (0.67) | L3MBTL1TDP1SMN1; SMN2HRH4HRH3 | |
| SCHEMBL9011624 | 0.72 | TSHR (0.67) | L3MBTL1TDP1SMN1; SMN2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074805-A | GLS1 inhibitor for treating disease | 德州大学系统董事会 | 2017-08-18 | — | — | CN | disclosed |