Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537317 | 0.85 | HTR2A (0.68) | OPRM1OPRK1HTR2AACHEOPRL1 | |
| SCHEMBL13145308 | 0.85 | HTR2A (0.45) | OPRM1OPRK1HTR2AACHEOPRL1 | |
| SCHEMBL537460 | 0.76 | HTR2A (0.60) | HTR2AMEN1KMT2ADRD2HTR2C | |
| SCHEMBL13172552 | 0.75 | HTR2A (0.46) | HTR2ADRD2HTR2CKCNH2 | |
| SCHEMBL13134073 | 0.74 | HTR2A (0.45) | HTR2AACHEMEN1KMT2ADRD2 | |
| SCHEMBL537249 | 0.74 | HTR2A (0.45) | HTR2AKMT2ADRD2HTR2CKCNH2 | |
| SCHEMBL7958107 | 0.72 | HTR2A (0.73) | OPRM1OPRK1HTR2ADRD2HTR2C | |
| SCHEMBL14280680 | 0.71 | OPRM1 (1.00) | OPRM1OPRK1HTR2AACHEOPRL1 | |
| SCHEMBL13172803 | 0.69 | ACHE (0.46) | OPRM1OPRK1HTR2AACHEOPRL1 | |
| SCHEMBL8934886 | 0.68 | ROCK1 (0.56) | OPRM1OPRK1ACHEOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | MKI67, CCNI, CDK4 | OPRM1 2788/4885OPRK1 1322/4885HTR2A 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.