Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.60 |
| ▸ | HTR2C | P28335 | 7/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13172552 | 0.79 | HTR2A (0.46) | HTR2AHTR2CKCNH2NPC1GBA1 | |
| SCHEMBL537317 | 0.79 | HTR2A (0.68) | HTR2AHTR2CKCNH2HSD17B10DRD2 | |
| SCHEMBL13134073 | 0.78 | HTR2A (0.45) | HTR2AHTR2CKCNH2MEN1LMNA | |
| SCHEMBL537249 | 0.78 | HTR2A (0.45) | HTR2AHTR2CKCNH2TLR8TLR7 | |
| SCHEMBL31060925 | 0.76 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7962369 | 0.76 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL2817646 | 0.76 | OPRM1 (0.55) | HTR2AHTR2CKCNH2MEN1KMT2A | |
| SCHEMBL8316644 | 0.74 | HTR2C (0.69) | HTR2AHTR2CKCNH2ADRB2TLR9 | |
| SCHEMBL537396 | 0.72 | HTR2A (0.54) | HTR2AHTR2CKCNH2TLR9TLR8 | |
| SCHEMBL31285825 | 0.71 | HTR2A (0.65) | HTR2AHTR2CKCNH2ADRB2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2414344-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114896-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | MKI67, CCNI, CDK4 | HTR2A 177/4885HTR2C 113/4885KCNH2 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.